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Understanding Your Test Results

What tests did you do?

Antibodies are made by your body to fight infections. Usually, they are made in response to either past infection by a virus or vaccination. This study checked 3 things:

  • The SARS-CoV-2 Spike ACE2 test looks at how much of the original COVID-19 strain would be blocked by your antibodies.
  • The SARS-CoV-2 Omicron Spike ACE2 test estimates how much of the Omicron strain of COVID-19 would be blocked by your antibodies.
  • The SARS-CoV-2 Spike IgG test checks the level of COVID-19 antibodies in your blood.

What do these results mean? What levels are “normal”?

The SARS-CoV-2 Spike ACE2 test estimates how much of the original COVID-19 strain would be blocked by your antibodies. A previous study found that antibodies in people 1 week to 2 months after vaccination blocked an average of 67.9% of the virus-cell interactions, and 12.2% of the interactions were blocked by antibodies in people about 3-4 months after natural infection.

The SARS-CoV-2 Omicron Spike ACE2 test estimates how much of the Omicron COVID-19 strain would be blocked by your antibodies. We do not know how much antibodies against one strain of COVID-19 protect people against other strains; that is one of the things we hope to learn from this study.

The SARS-CoV-2 Spike IgG test shows the level of COVID-19 antibodies you had in your blood when you gave the blood sample. Usually your antibody levels will go up after getting a vaccine or having an infection. Having more antibodies means your body can fight infection better than having fewer antibodies. A previous study found that on average, people had antibody levels of around 1,000,000 AU/mL 1 week to 2 months after their vaccination, and around 10,000 AU/mL 3-4 months after a COVID-19 infection.

Do my results mean I am immune to COVID-19?

Having antibodies does not always mean that you are immune to COVID-19. One of the goals of this study is to determine which of these three tests best predicts protection from infection and/or serious illness from COVID-19. At this time, please continue to follow the recommended public health guidelines to protect yourself and your loved ones.

How can I learn more about antibody testing?

You can find a more detailed scientific explanation of the ZAP COVID study by downloading the PDF below:

In addition, the CDC has resources on antibody testing at the links below: